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Filtered Search Results
Chemscene ChemScene | 8-Bromo-5-nitroquinoline | 5G | CS-0035507 | 0.98 | 139366-35-1| MFCD00509069 | 253.055
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ChemScene | 8-Bromo-5-nitroquinoline | 5G | CS-0035507 | 0.98 | 139366-35-1| MFCD00509069 | 253.055
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Medchemexpress LLC N-(1-phenylethyl)-2-pyrrolidin-1-ylquinazolin-4-amine | 662163-81-7 | MFCD04077630 | 99.9% | 318.42 g·mol^-1 | C20H22N4 | 200 MG
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Importazole is a small-molecule inhibitor of the nuclear transport receptor importin-β used in laboratory research to selectively block importin-β-mediated nuclear import. It is supplied as a white to off-white solid with documented solubility and storage recommendations for reliable use in cell biology studies. For research use only.
- Selective inhibitor of importin-β.
- High purity, typically about 99.9%.
- White to off-white solid form.
- Soluble in DMSO; in vitro and in vivo formulation protocols available.
- Stable under recommended storage conditions for powder and solutions.
- Intended for research use only; not for therapeutic use.
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TARGETMOL CHEMICALS INC LM22A-4 25MG
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Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 47 nM in a fluorescence anisotropy assay) Purity ≥95%
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000379286 ICG-AMINE 1MG
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Apexbio Technology LLC Androgen receptor antagonist 9 915086-32-7 200mg
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Androgen receptor antagonist 9 (CAS 915086-32-7) is a small molecule inhibitor that binds to the androgen receptor (AR) thereby preventing androgens such as testosterone and dihydrotestosterone from interacting with the receptor By disrupting AR signaling pathways this compound can suppress the proliferation and growth of tumor cells in androgen-dependent malignancies Androgen receptor antagonist 9 is utilized in research investigating the pathogenesis and treatment of diseases such as prostate cancer where androgen signaling is implicated
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Apexbio Technology LLC Ro 31-8220 125314-64-9 50mg
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Ro 31-8220 (CAS 125314-64-9) is a potent and selective inhibitor of protein kinase C (PKC) targeting isoforms PKC- (IC50 5 nM) PKC- I (24 nM) PKC- II (14 nM) PKC- (27 nM) and PKC- (24 nM) PKC is a Ca2 and phospholipid-dependent serine/threonine kinase involved in signaling pathways regulating cell proliferation and malignancy Ro 31-8220 modulates downstream signaling by inducing c-Jun expression and activating JNK1 while inhibiting MKP-1 and c-Fos expression independent of PKC activity In immunological studies it suppresses IL-2 production (IC50 80 nM) T cell proliferation (IC50 350 nM) and CD25 expression indicating inhibition of both early and late T cell activation Ro 31-8220 is widely utilized in cellular and molecular studies to dissect PKC-dependent and independent signaling mechanisms
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Apexbio Technology LLC GI-530159 69563-88-8 200mg
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GI-530159 (CAS 69563-88-8) is a small molecule activator selective for the TREK1 and TREK2 two-pore domain potassium channels exhibiting greater specificity for TREK1/2 over other related channels such as TRAAK and TASK3 It has been shown to potentiate TREK1 channel activity with an EC50 of 0 76 M In experimental models GI-530159 reduces excitability in rat dorsal root ganglion neurons indicating its capability to modulate neuronal activity These properties highlight its utility as a pharmacological tool in studies related to neuronal excitability pain pathways and the pathophysiology of neurological disorders involving potassium channel dysfunction
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TARGETMOL CHEMICALS INC Piribedil 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease. Purity 99.91%
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Medchemexpress LLC Pacma 31 | 1401089-31-3 | 99.3% | 430.47 g·mol⁻1 | C21H22N2O6S | 100 MG
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PACMA 31 is an irreversible small-molecule inhibitor of protein disulfide isomerase (PDI) used in biochemical and cellular research. It covalently modifies active-site cysteines, has shown tumor-targeting activity in preclinical studies, and contains an alkyne moiety that enables copper-catalyzed azide-alkyne cycloaddition for conjugation and probe development.
- Irreversible inhibitor of protein disulfide isomerase for biochemical and cellular assays.
- Forms covalent bond with active-site cysteines for sustained target engagement.
- Contains an alkyne group suitable for click chemistry conjugation.
- High purity suitable for research use.
- Available in multiple pack sizes for flexible experimental needs.
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Medchemexpress LLC EGFR-IN-86 | 3055550-22-3 | 99.9% | 423.49 | 25 MG
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EGFR-IN-86 is an EGFR inhibitor with an IC50 of 1.5 nM. It shows high activity against glioblastoma, inducing apoptosis and arresting U87 cell cycles in the G2/M phase. This product is for research use only and not sold to patients.
- Potent EGFR inhibitor
- High activity against glioblastoma
- Induces apoptosis
- Arrests U87 cell cycles in G2/M phase
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Medchemexpress LLC Tertiapin-Q | 910044-56-3 | 99.8% | 2452.00 | 5 MG
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Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1) potassium channels, intended for research use only. It also potently and selectively blocks Kir3.1-Kir3.4 channels and calcium-activated large conductance potassium channels, blocking somatostatin (SS-14)-activated current. As a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker, Tertiapin-Q significantly prolongs the atrial effective refractory period (AERP).
- Highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1) potassium channels
- Potently and selectively blocks Kir3.1-Kir3.4 and calcium-activated large conductance potassium channels
- Blocks somatostatin (SS-14)-activated current
- Functions as a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker
- Prolongs atrial effective refractory period (AERP)
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eMolecules 54013-06-8 | 5-Amino-pyrazine-2-carboxylic acid ethyl ester | J&W PharmLab LLC | MFCD08437665 | 167.168 | C7H9N3O2 | 96.000 | CCOC(=O)c1cnc(N)cn1 | 500mg | 571064491
5-Amino-pyrazine-2-carboxylic acid ethyl ester | J&W PharmLab LLC | 54013-06-8 | MFCD08437665 | 167.168 | C7H9N3O2 | 96.000 | CCOC(=O)c1cnc(N)cn1 | 500mg | 571064491
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Medchemexpress LLC Cinchonidine (α-Quinidine) | 485-71-2 | 99.6% | 294.39 | 100 G
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Cinchonidine (α-Quinidine) is a cinchona alkaloid found in *Cinchona officinalis* and *Gongronema latifolium*. It is a building block used in asymmetric synthesis in organic chemistry. It acts as a weak inhibitor of the serotonin transporter (SERT) and exhibits antimalarial activities.
- Derived from *Cinchona officinalis* and *Gongronema latifolium*
- Used as a building block in asymmetric synthesis
- Weak inhibitor of the serotonin transporter (SERT)
- Exhibits antimalarial activities
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Medchemexpress LLC Almonertinib (mesylate) | 2134096-06-1 | 99.7% | 621.75 | 1 ML
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Almonertinib mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor. It shows high selectivity for EGFR-sensitizing and T790M resistance mutations, with inhibitory activity against T790M, T790M/L858R, and T790M/Del19. It is used for the research of non-small cell lung cancer (NSCLC). This compound can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available inhibitor
- Irreversible, third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Inhibitory activity against T790M, T790M/L858R, and T790M/Del19
- Less effective against wild type EGFR
- Used for non-small cell lung cancer research
- Can inhibit other EGFR sensitive mutations like G719X, del19, L858R, and L861Q
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Selleck Chemical LLC Kynurenic acid-100mg
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Kynurenic acid (Quinurenic acid, Kynurenate), a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPAreceptors.
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